Rui, Xu-Kai and Li have contributed an article in RNA Biol. Congratulations to Rui, Xu-Kai and Li!
Xu-Kai, Zheng and Li took part in the Cold Spring Harbor Asia conference on RNA Biology and Li delivered a presentation.
Rui and Wei participated in Cell Symposia Functional RNAs and Rui presented his latest public researches in the poster presentations.
Our lab participated in city hiking and won the third prize.
Zheng, Jian-Feng and Li have contributed an article in Mol Cell. Congratulations to Zheng, Jian-Feng and Li!
The authors have employed a variety of techniques including RNA immunoprecipitation and deep sequencing to explore the repertoire of snoRNA related lncRNAs. These approaches allowed the authors to identify a type of polycistronic transcript derived lncRNAs that are 5' snoRNA capped and 3' polyadenylated (SPAs). SPA processing is associated with nascent mRNA 3’ processing and kinetic competition between XRN2 trimming and Pol II elongation. Following cleavage/polyadenylation of its upstream gene, the downstream uncapped pre-SPA is trimmed by XRN2 until this exonuclease reaches the co-transcriptionally assembled snoRNP. This snoRNP complex prevents further degradation, generates a novel 5' end and allows continuous Pol II elongation. The imprinted 15q11-q13 encodes two SPAs that are deleted in Prader-Willi syndrome (PWS) patients. These PWS region SPAs, together with previously identified sno-lncRNAs (Yin et al., Mol Cell, 2012) form a nuclear accumulation that is enriched in multiple RNA binding proteins (RBPs) including TDP43, RBFOX2 and hnRNP M. Generation of a human PWS cellular model by depleting these lncRNAs results in altered patterns of RBPs binding and alternative splicing. Prader-Willi Syndrome is a multiple-system human disorder including global developmental delay, mental retardation, morbid obesity, and etc. These findings thus implicated previously unannotated class of lncRNAs in PWS pathogenesis during early embryonic development and adulthood.
Zheng, Qin and Li have contributed a preview in Mol Cell. Congratulations to Zheng, Qin and Li.
Rui has obtained National Scholarship for Outstanding Graduate Student, Ministry of Education of the People's Republic of China. Congratulations to Rui!
Rui took part in the second circular RNA Research Forum and delivered a presentation.
Rui and Wei participated in the 2016 joint annual meeting of the RNA Society and the RNA Society of Japan and presented their latest public researches in the poster presentations.
We have published a collaborative work with Chen Lab in Genome Res. Congratulations to Xiao-Ou, Rui, Jia-Lin, Zheng and Li.
Xiao-Ou has passed the dissertation defense! He becomes the first Ph.D graduate of our lab! Congratulations to Xiao-Ou!
Welcome new graduate student Meng-Ran to join our group!
Our lab has contributed an article in Cell Reports. Congratulations to Wei, Jia-Lin and Li.
Our lab has contributed a letter in Cell Res. Congratulations to Rui, Xiao-Ou, Xu-Kai and Li.
Xiao-Ou has obtained 2016 Shanghai outstanding graduates and 2016 Shanghai tri-merit student honor award. Congratulations to Xiao-Ou.
Welcome new graduate students Kai-Xuan and Ying to join our group!
Li has contributed a chapter of Long Non-Coding RNAs. Congratulations to Li!
Rui and Li have contributed an article in Cell Res. Congratulations to Rui and Li!